Buy Nitromethaqualone online (CAS Number: 340-52-3)
Buy Nitromethaqualone (CAS Number: 340-52-3) is a quinazolinone-class central nervous system depressant that acts as a sedative and hypnotic research compound. It is a structural derivative of methaqualone, modified with a nitro group on the phenyl ring, which alters its potency and pharmacological profile.
According to sources such as PsychonautWiki and a Cayman Chemical safety data sheet, Nitromethaqualone interacts with GABA_A receptor sites, enhancing inhibitory signalling in the brain, which explains its strong sedative and muscle-relaxant profile. In research contexts, it is treated as a high-risk psychoactive reference standard that requires strict handling controls and clear documentation.
Composition and Structure
Nitromethaqualone shares a structural analogue relationship with metaqualone, a sedative drug known for its hypnotic effects. This relationship stems from the similarities in their chemical structures, with nitromethaqualone exhibiting certain modifications that result in increased potency. Chemically, nitromethaqualone is composed of specific molecular components that contribute to its sedative properties, making it a compelling option for those seeking effective sedation.

| Synonyms | Nitromethaqualone |
| IUPAC | 3-(2-methoxy- |
| Formula | C16H13N3O4 |
| Molecular weight | 311.3 g·mol |
| CAS | 340-52-3 |
| Purity | ≥ 98% |
Potency and Dosage
Why researchers care about Nitromethaqualone (pharmacology, structure, effects)
Chemically, Nitromethaqualone is often described as 3,4-dihydro-2-methyl-3-(2-nitrophenyl)-4-oxoquinazoline, which reflects its quinazolinone core and nitro-substituted phenyl group. This structure places it in the same broad family as older sedative-hypnotics studied in the 1960s and 1970s, although Nitromethaqualone itself has far less formal clinical literature than methaqualone.
Reports aggregated on PsychonautWiki describe Nitromethaqualone as a strong CNS depressant with physical effects such as sedation, dizziness, muscle relaxation, motor control loss, and risk of respiratory depression at higher exposures. A Cayman Chemical data sheet lists oral and intraperitoneal LD50 values in mice (around the low gram per kilogram range), underlining that this is not a benign compound and belongs firmly in a hazardous research-only category.
How does Nitromethaqualone (CAS 340-52-3) work?
Laboratory and theoretical data frame Nitromethaqualone as a GABAergic modulator, similar in broad concept to benzodiazepines or barbiturates, by enhancing GABA-mediated inhibition in the central nervous system. This mechanism explains the typical sedative, hypnotic, and muscle relaxant characteristics that attract interest in pharmacological and forensic research.
However, although analogous compounds like methaqualone are extensively archived on platforms such as DrugBank and Drugs.com, public databases contain far fewer peer-reviewed pharmacokinetic studies on Nitromethaqualone itself, which is why credible suppliers and reference documents stress that its use must be restricted to controlled analytical work, not experimentation on humans.
Nitromethaqualone risks, safety profile, and toxicity
Available safety data for Nitromethaqualone classify it as toxic if misused and suitable only for trained personnel in controlled environments. The Cayman Chemical safety sheet notes mouse LD50 values around 930 to 982 mg/kg, with standard warnings relating to respiratory depression, CNS depression, and general toxicological uncertainty when extrapolated outside controlled laboratory settings.
Subjective-effect descriptions compiled on PsychonautWiki emphasise profound sedation, lethargy, motor impairment, and risk of respiratory depression at higher doses, which, in a non-clinical environment, would represent a serious safety threat. According to harm reduction sources such as TripSitter, similar sedative-hypnotic research chemicals have been linked to confusion, accidents, and risky polydrug use patterns, especially when combined with alcohol, opioids, or benzodiazepines.
Legal status and ethical sourcing of Nitromethaqualone
Formal scheduling for Nitromethaqualone varies by jurisdiction, but many countries now regulate methaqualone analogues and other novel sedative-hypnotics under analogue, psychoactive substances, or medicines legislation. In practice, this pushes Nitromethaqualone into a legal grey or controlled space, where only accredited laboratories, universities, or forensic institutions with appropriate permits can handle it legitimately.
European regulatory texts describe how new psychoactive substances and precursors are increasingly placed under control regimes that restrict use to tightly defined scientific, analytical, and forensic applications. For that reason, ethical sourcing from a trusted lab-focused supplier such as the Davechemicals.com official website is essential for any group that wants to remain compliant and maintain transparent documentation of procurement, batch data, and intended use.
Why buy Nitromethaqualone (CAS 340-52-3) from Davechemicals.com? 🧪
At Davechemicals.com, our role is simple: we supply high-purity research chemicals to verified laboratories that know exactly what they are doing, and we do it with clarity and honesty rather than marketing fluff. Nitromethaqualone (CAS Number: 340-52-3) sits in a niche corner of the sedative-hypnotic landscape, so we treat it with high scrutiny and strict internal quality standards.[2]
Researchers who explore Davechemicals.com shop gain access to an extensive portfolio of controlled research standards, ranging from isopropylbenzylamine and benzocaine powder through to more specialised cannabinoids such as JWH-250 and JWH-018. This broader context matters, because many labs working with Nitromethaqualone also carry out comparative work on GABAergic depressants, synthetic cannabinoids, and novel opioids, and prefer keeping sourcing under one accountable roof.
How Nitromethaqualone compares with other sedative research compounds
Below is an at-a-glance comparison for researchers who also work with other depressant and psychoactive standards such as benzodiazepines, nitazenes, and synthetic cannabinoids.[1][2]
Table 1: Sedative-type research compounds compared
Sedative and depressant research standards from Davechemicals.com
| Compound | Primary class | Main researched effect | Typical research use | Example related product on Davechemicals.com |
|---|---|---|---|---|
| Nitromethaqualone (CAS 340-52-3) | Quinazolinone CNS depressant | Sedative, hypnotic, muscle relaxation | Reference standard for analytical and forensic work on sedative-hypnotics | Nitromethaqualone (CAS 340-52-3) via Davechemicals.com |
| Flualprazolam | Triazolo-benzodiazepine CNS depressant | Strong anxiolytic and sedative research profile | LC-MS / GC-MS benzodiazepine panel calibration | Buy flualprazolam online |
| Flunitrazepam | Benzodiazepine hypnotic | Powerful sedation, amnesia in clinical history | Forensic toxicology reference in benzodiazepine screening | Buy flunitrazepam for sale online |
| Bretazenil | Partial agonist benzodiazepine | Anxiolytic and sedative but with a partial agonist profile | Receptor binding and comparative potency studies | Buy bretazenil online |

